GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs2028299 | 1 | rs1371135 | chr15:90391270 | AP3S2 | chr15:90373832-90456222:- | -0.49 | -13.05 | 3.34E-36 | Type 2 diabetes |
| BRCA | cis | rs798766 | 1 | rs1374469 | chr4:1724799 | FAM53A | chr4:1641609-1685854:- | -0.21 | -5.47 | 5.64E-8 | Urinary bladder cancer;Bladder cancer |
| BRCA | cis | rs1668357 | 1 | rs1376260 | chr7:37991523 | EPDR1 | chr7:37960163-37991539:+ | -0.25 | -4.29 | 1.97E-5 | Myopia (pathological) |
| BRCA | cis | rs1668357 | 1 | rs1376261 | chr7:37991389 | EPDR1 | chr7:37960163-37991539:+ | -0.25 | -4.33 | 1.66E-5 | Myopia (pathological) |
| BRCA | cis | rs7692995 | 1 | rs1380293 | chr4:18027235 | NCAPG | chr4:17812525-17846485:+ | 0.09 | 4.14 | 3.74E-5 | Height |
| BRCA | cis | rs10043228 | 1 | rs1382339 | chr5:115558163 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 5.06 | 4.95E-7 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs10043228 | 1 | rs1382340 | chr5:115558161 | COMMD10 | chr5:115420727-115628978:+ | 0.24 | 5.06 | 4.95E-7 | Asthma or chronic obstructive pulmonary disease |
| BRCA | cis | rs6452524 | 1 | rs1382369 | chr5:82441429 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.54 | 0.000411 | Hypertension |
| BRCA | cis | rs6452524 | 1 | rs1382371 | chr5:82441119 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.54 | 0.000411 | Hypertension |
| BRCA | cis | rs6452524 | 1 | rs1382372 | chr5:82441056 | XRCC4 | chr5:82373317-82649577:+ | -0.12 | -3.54 | 0.000411 | Hypertension |
| BRCA | cis | rs138544659 | 1 | rs138544659 | chr15:78900701 | AGPHD1 | chr15:78799906-78829714:+ | -0.16 | -3.73 | 0.000198 | Post bronchodilator FEV1;Emphysema distribution in smoking;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs138544659 | 1 | rs138544659 | chr15:78900701 | CHRNA5 | chr15:78857906-78886458:+ | -0.2 | -6.06 | 1.93E-9 | Post bronchodilator FEV1;Emphysema distribution in smoking;Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1/FVC ratio |
| BRCA | cis | rs2087017 | 1 | rs1385884 | chr3:113841625 | GRAMD1C | chr3:113547029-113666020:+ | 0.11 | 3.39 | 0.000714 | Personality dimensions |
| BRCA | cis | rs2076028 | 1 | rs138702 | chr22:39132601 | APOBEC3C | chr22:39410265-39414823:+ | 0.11 | 4.03 | 5.89E-5 | Resting heart rate |
| BRCA | cis | rs2076028 | 1 | rs138702 | chr22:39132601 | JOSD1 | chr22:39081549-39096459:- | 0.14 | 4.62 | 4.35E-6 | Resting heart rate |